SrasV1, Main, Exploration, bibRecord, 004719

Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.

Identifieur interne : 004719 ( Main/Exploration ); précédent : 004718; suivant : 004720

Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.

Auteurs : Peng Tao [République populaire de Chine] ; Jun Zhang ; Ni Tang ; Bing-Qiang Zhang ; Tong-Chuan He ; Ai-Long Huang

Source :

Chinese medical journal [ 0366-6999 ] ; 2005.

RBID : pubmed:15899131

Descripteurs français

KwdFr :
- Antigènes viraux (génétique), Cellules cultivées, Humains, Interférence par ARN, Protéines nucléocapside (antagonistes et inhibiteurs), Protéines nucléocapside (génétique), Protéines à fluorescence verte (génétique), Syndrome respiratoire aigu sévère (), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
MESH :
- antagonistes et inhibiteurs : Protéines nucléocapside.
- génétique : Antigènes viraux, Protéines nucléocapside, Protéines à fluorescence verte, Virus du SRAS.
- immunologie : Virus du SRAS.
- Cellules cultivées, Humains, Interférence par ARN, Syndrome respiratoire aigu sévère, Vecteurs génétiques.

English descriptors

KwdEn :
- Antigens, Viral (genetics), Cells, Cultured, Genetic Vectors, Green Fluorescent Proteins (genetics), Humans, Nucleocapsid Proteins (antagonists & inhibitors), Nucleocapsid Proteins (genetics), RNA Interference, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (therapy).
MESH :
- chemical , antagonists & inhibitors : Nucleocapsid Proteins.
- chemical , genetics : Antigens, Viral, Green Fluorescent Proteins, Nucleocapsid Proteins.
- genetics : SARS Virus.
- immunology : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- Cells, Cultured, Genetic Vectors, Humans, RNA Interference.

Abstract

Severe acute respiratory syndrome (SARS) is an infectious disease caused by SARS-CoV. There are no effective antiviral drugs for SARS although the epidemic of SARS was controlled. The aim of this study was to develop an RNAi (RNA interference) approach that specifically targeted the N gene sequence of severe acute respiratory syndrome associated coronavirus (SARS-CoV) by synthesizing short hairpin RNA (shRNA) in vivo, and to assess the inhibitory effect of this shRNA on SARS-CoV N antigen expression.

PubMed: 15899131

Affiliations:

République populaire de Chine

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an infectious disease caused by SARS-CoV. There are no effective antiviral drugs for SARS although the epidemic of SARS was controlled. The aim of this study was to develop an RNAi (RNA interference) approach that specifically targeted the N gene sequence of severe acute respiratory syndrome associated coronavirus (SARS-CoV) by synthesizing short hairpin RNA (shRNA) in vivo, and to assess the inhibitory effect of this shRNA on SARS-CoV N antigen expression.</div>
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<name sortKey="Tang, Ni" sort="Tang, Ni" uniqKey="Tang N" first="Ni" last="Tang">Ni Tang</name>
<name sortKey="Zhang, Bing Qiang" sort="Zhang, Bing Qiang" uniqKey="Zhang B" first="Bing-Qiang" last="Zhang">Bing-Qiang Zhang</name>
<name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name>
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Serveur d'exploration SRAS

Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.

Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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